Opsumit

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Opsumit treats pulmonary arterial hypertension. Do not chew, divide, or break Opsumit tablets. Swallow Opsumit tablets whole.

Opsumit Overview

Reviewed: March 26, 2018
Updated: 

Opsumit is a prescription medication used to treat pulmonary arterial hypertension (PAH). PAH causes high blood pressure in the vessels that carry blood to the lungs. 

Opsumit belongs to a group of drugs called endothelin receptor antagonists. These work by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.

This medication comes in tablet form and is taken by mouth once daily, with or without food. Do not chew, divide, or break Opsumit tablets. Swallow Opsumit tablets whole.

Common side effects of Opsumit include low red blood cell counts (anemia), pharyngitis (swelling in the throat), and bronchitis. 

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Opsumit FDA Warning

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WARNING: EMBRYO-FETAL TOXICITY

  • Do not administer Opsumit to a pregnant female because it may cause fetal harm. 
  • Females of reproductive potential: exclude pregnancy before start of treatment, monthly during treatment, and 1 month after stopping treatment.Prevent pregnancy during treatment and for one month after treatment by using acceptable methods of contraception.
  • For all female patients, Opsumit is available only through a restricted program called the Opsumit Risk Evaluation andMitigation Strategy (REMS).