Apadaz

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Apadaz treats severe pain. Apadaz should be used for no more than 14 days. Crushing, grinding, smoking, or vaporizing Apadaz will not release hydrocodone, the active narcotic that is often abused.

Apadaz Overview

Reviewed: February 26, 2018
Updated: 

Apadaz is a prescription medication used to treat acute and severe pain. It is a single product containing 2 medications: benzhydrocodone and acetaminophen.

Benzhydrocodone belongs to a group of drugs called opiate analgesics (narcotic pain relievers). These relieve pain by changing the way the brain responds to pain. Acetaminophen belongs to a group of drugs called analgesics (pain relievers). These relieve pain by changing the way the body senses pain. 

This medication comes in tablet form and is taken up to 6 times a day. Do not take more than 12 tablets in 24 hours. 

Common side effects of Apadaz include nausea, tiredness, vomiting, constipation, itching, dizziness and headache.

Apadaz can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how Apadaz affects you.

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Apadaz Drug Class

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Apadaz is part of the drug class:

Apadaz FDA Warning

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Apadaz exposes users to risks of addiction, abuse, and misuse, which can lead to overdose and death. Assess patient’s risk before prescribing and monitor regularly for these behaviors and conditions.

Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely, especially upon initiation or following a dose increase.

Accidental ingestion of Apadaz,especially by children, can result in a fatal overdose of hydrocodone.

Prolonged use of Apadaz during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. If prolonged opioid use is required in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.

Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of hydrocodone from Apadaz. 

Apadaz contains acetaminophen. Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

Concomitant use of opioids with benzodiazepines orother central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for use in patients for whom alternative treatment options are inadequate; limit dosages and durations to the minimum required; and follow patients for signs and symptoms of respiratory depression and sedation.